Carboxylic acid amides

ABSTRACT

The present invention provides carboxylic acid amides of the formula   IN WHICH X represents methyl or tertiary butyl, m is the integer 1 or 2, Q represents hydrogen, alkyl, alkylidene, cycloalkylidene, substituted methylene, alkylene, alkenylene or a 3,4,5 or 6-valent saturated aliphatic hydrocarbon radical and p represents an integer which corresponds to the valency of the radical Q. These carboxylic acid amides are suitable for stabilizing organic materials sensitive to oxidations.

United States Patent Huber-Emden et a].

CARBOXYLIC ACID AMIDES lnventors: Helmut Huber-Emden; Karl Eschle,

both of Basel; Arthur Maeder, Therwil, all of Switzerland Ciba-Geigy Corporation, Ardsley, N.

Assignee:

Filed: Sept. 4, 1970 Appl. No.: 69,886

Related US. Application Data Continuation-impart of Ser. No. 737,832, June 18, 1968, abandoned.

Foreign Application Priority Data June 23, I967 Switzerland 8947/67 [1.8. Cl....260/559 T; 260/95.8 A; 260/45.9 NC; 260/347.2; 260/429 K; 260/4297;

260/429.9; 260/435 R; 2601438.]; 260/4385 R; 260/439 R; 260/454; 260/456 A; 260/470; 260/516; 260/558 S; 252/402 Int. Cl. C07C 103/38 Field of Search 260/562, 559, 347.2

References Cited UNITED STATES PATENTS l2/l948 Prill 260/338 l2ll973 Knell 260/559 [l l] 3,927,09 l

[ Dec. 16, 1975 Primary Examiner-Harry l. Moatz Attorney, Agent, or Firm-Charles W. Vanecek; Vincent J. Cavalieri; Nestor W. Shust [57] ABSTRACT The present invention provides carboxylic acid amides of the formula 10 Claims, No Drawings CARBOXYLIC ACID AMIDES This application is a continuation-in-part of Ser. No. 737.832. filed June 18. 1968, now abandoned.

The present invention provides the new carboxylic acid amides of the formula in which R represents a benzene residue which contains a hydroxyl group in orthoor para-position to the CH group and as further substituents two hydrocarbon residues. R represents a hydrogen atom a possibly substituted alkyl radical containing 1 to 20. preferably l to 18 carbon atoms. a possibly substituted aryl radical. a residue of the formula in which R and m have the above meanings. or a residue of the formula C (l' SO cation are formed by the reaction in the presence of an alkaline catalyst of a compound of the formula (3) ll R,CHENHCCH=CH2 with a monomercaptoalkyl compound in the molar ratio 1:1 or with a dimercaptoalkyl compound in the molar ratio 2:1.

The compounds needed as starting materials for lllls additive reaction can be manufactured from dialkylhydroxybenzenes and acrylylmethylolamide by the socalled Tscherniak condensation. Then it is possible to add mercapto compounds. for example simple alkyl mercaptans such as n-propylmercaptan or n-dodecylmercaptan on to the double bond of the resulting condensation products of the formula (2 The alkyl groups of these mercaptans may also contain substitu ents. for example such as can be further reacted such as carboxylic acid alkyl ester groups. If the compounds of the formula (3) are to be reacted with alkane dithoils. this is advantageously performed at a molecular ratio of 2 l. and the two mercapto groups add on to a double bond each of the two molecules of the acrylic acid derivative. Alkaline catalysts suitable for the additive reaction are. for example, sodium ethylate or benzyl trimethyl ammonium hydroxide.

Compounds of the formula (in which R. m and n have the above meanings) are obtained when a compound of the formula (in which R and m likewise have the above meanings) are reacted at a molecular ratio of 2 l with a sodium sulphide of the formula Na s where n is a digit not exceeding 7. for example 1. 2 or 5. The halogen compounds of the formula (5) are obtained. as described for the compounds of the formula (3 J. by Tscherniak condensation of dialkylhydroxybenzenes with halogenalkanecarboxylic acid methylolamides containing 1 or 2 carbon atoms in the alkane residue. for example chloropropionylmethylolamide or preferably chloroacetylmethylolamide. The condensation of the halogen compounds of the formula (5) with the sodium sulphides is advantageously conducted in a neutral organic solvent; sodium sulphides that contain more than one sulphur atom for every two sodium atoms. can be manufactured in such solvents. for example in methanol. immediately before the condensation and without intermediate isolation. from Na s and elemental sulphur.

Compounds of the formula (4]. in which m 2. are obtained when H 5 is added on. in the presence of a minimal quantity of NaHS. to compounds of the formula (3). for example c(ca o 2 HO- -ca -mi-iica=ci1 3 s (x021 J X 19 Compounds of the formula in which R and m have the above meanings and R" is a possibly substituted alkyl radical. an aryl radical or a residue of the formula W are condensed with mercapto compounds of the for mula H-S-R'Q. in which R": represents a possibly substituted alkyl or aryl radical. or when compounds of the 35 formula 10) are condensed with dimercapto comfor example. alk \l groups such as ethyl or methyl. alkoxy groups such as ethoxy or methoxy. or halogen atoms. especially chlorine,

Carboxylic acid amides of the formula in which R and m have the above meanings and r is a digit from 1 to 2i). preferably from l to 18. are manufactured by condensing 2 mols of a mercaptan of the formula with l mol of an aldehyde of the formula (m o=CH icH .i:-. H Compounds of the general formula (8) are obtained. for example. when intermediates of the formula (5) are condensed in stoichiometric amounts with other polyfunctional mercapto compounds. for example C(CH (14) 5 5 3 -2 HQ]. (8) 2 ao- CH NH c c3 01 H-(s-ca -sH polythioformal C(OH pounds of the formula H-S-alkylene-S-H at a molecular r 2 to 5 on an average 35 C(CH C(CH (15) 5 5 q 4 0 f 5 5 X H HO- GH -NH-C-CH (S-CH o-CH C-NH-CH OH ,C( :tt MCI-I ratio of 2 1. When a halogen compound containing a b. 4 mols of the compound of the formula l4) 0 +HCl V 5 0 o HS-CH -ii-o-ca 7 no -CH ant-54H -SCH --oca l 4W5 l-rl an ters. As suitable aryl radicals there may be specially mentioned benzene residues containing as substituents.

C(CH

Compounds of the general formula [8) (m 1: R" substituted alkyl radical) are also obtained when mercaptans of the general formula in which R has the above meaning are added on to formaldehyde at a molecular ratio of 1 l. for example:

5 6 Compounds of the general formula (8) (m l. R", W Y r substituted alkyl radical) are also obtained. for exam- 3n plea when mercaptans of the general formula l3) are QH L condensed with aldehydes or ketones at a molecular 3 ratio of 2 l. for example: 2 Mols of the compound of (Ht|. 2 the formula l8) 3 -1CH -1.

o 0/115 $220 HO 3 m NH 3 CH s \c/R5 g 2 2 \R (K03 2 where 5 2 s' z in CH CH 2 2 CH R -a '-H r -n 2 2 The preferred compounds correspond to the formula 25 34 t- 3 3s C H l o 'I V15! R (H -\H Cl(H;l,,,-$lAl s: 3) 3h 4 9" in which R and m have the above meanings. s l or 2. 37 g l 6 p is a digit from 1 to 6. B represents a p-valent. possibly substituted alkyl radical which may contain vinyl groups. and A represents a residue of the formula are obtained by condensing p Thus, carboxylic acid amides manufactured from mols of a mercaptan of the formula polyfunctional alkylhalides. preferably correspond to the formula 0 ll lzm R,CH 'NHCICHLATSH T R.-cH. NH C iCH i,,. -s- [CH .IB,JJIT] in form of its alkali metal salt with 1 mol of a p-functional alkylhalide of the formula (27) YZ Compounds of the general formula (8) (m l; R": or substituted alkyl radical) are also obtained when mercaptans of the formula l7) in form of their alkali metal salts are condensed in stoichiometric proportions with suitablepossibly polyfunctional alkylhalides. for S0 6ample: (39) R,CH .-NHC(CH .|,.,-S-(AL pi l t-l 0 ll v p. HO- -cn NH c CH s Na $2 p.NaZ

away;

29) (0x9 0 11 HO- -CH NHCGH -S [Y] Z represents a chlorine or bromine atom and p= l to 6, n5 which and have the ilbQVfi meanings l pr In the compounds of the formula (29) thus obtained a residue of the formula (CH1 l" whlch the symbols Y and 1) have. for example. the following g g i g g g z gf sg g gig g g i li meanings: or H or CHV.C-CH, l CH.

l l C l A stands for a residue of the formula CH COOCH- and m and .s' each is l or Z. and p is 3.4 or b.

The compounds of the formula l obtained by the manufacturing methods described above may be converted into other compounds. some of them likewise corresponding to this formula. when they contain suitable reactive groups. Thus. carboxylic acid amides of the formula (in which R and m have the above meanings. Me is a q-valent cation and q 1.2 or 3) are obtained when esters of the formula are hydrolyzed in an alkaline medium and. if desired.

the resulting carboxylic acid salts are converted into the free acids or into other salts. The hydrolysis is easy to achieve with a solution of sodium hydroxide in ethanol or methanol. When the sodium salt is acidified in an aqueous medium. the free acid is obtained. When these acids are subjected to a double reaction with alkaline earth metal salts or heavy metal salts. for example with the water-soluble salts of barium. cadmium. zinc. tin. lead. copper. nickel or chromium or with uranyl salts. the corresponding salts of the acids of the formula (40) are obtained. Such salts are in general sparingly soluble in water. but as a rule soluble in organic solvents such as benzene or methylenechloride.

Carboxylic acid amides of the formula (in which R and m have the above meanings and R' represents an atomic grouping of the formula anionor a hydrogen atom) are obtained when compounds of the formula (5) are reacted with thiourea and. if desired. the resulting thiuronium salt is split. for example with aqueous sodium hydroxide.

Furthermore. the compounds of the formula (5) may be reacted with alkalithiocyanates accompanied by eliminationl of alkali metal halide to yield compounds of the formula The residue R in carboxylic acid amides of the formula (l) is a benzene residue which contains a hydroxyl group in orthoor preferably in para-position to the CH group and as further suhstituents two hydrocarbon residues. As mentioned above. the resi due R is introduced into the intermediates used for the manufacture of the carboxylic acid amides by means of a corresponding hydroxybenzene that contains no substituent in at least one of the positions mentioned. being for example a l-hydroxy-Z.4. 3.4-. -2.3-. 2.5- or -3.5-dialkylbenzene. These hydroxydialkylbenzenes contain in addition to any desired hydrocarbon residue. for example an ethyl or a methyl group. advantageously as at least one further substituent an alkyl group with a carbon atom which hinders sterically and is bound direct with the benzene nucleus. such as a tertiary butyl. tertiary octyl or tertiary dodecyl group. or a cyclt hexyl residue. such as an unsubstituted cyclohexyl or the l'-methylcyclohexyl residue. or an a-phenylalkyl residue. for example the benzyl residue.

Preferred carboxylic acid amides of the formula l l contain a residue R of the formula in which X represents a methyl or tertiary butyl group.

The compounds of the formula l are suitable for stabilizing organic materials sensitive to oxidation. For this purpose they may be used in known manner for the following substrates;

Homopolymers and copolymers of ethylenically unsaturated compounds such as vinylchloride. vinylidenechloride. styrene. butadiene. isoprene. ethylene. propylene. derivatives of acrylic and methacrylic acid. for example acrylic acid alkyl esters. acrylic acid amides and acrylonitrile; polyamides. for example of ecaprolactam or of adipic acid and a diamine; polyesters such as polyterephthalic acid glycol esters; natural and synthetic rubbers; lubricating oils. gasolin; vegetable and animal oils and fats; waxes; cellulose and cellulose derivatives such as cellulose esters.

in general. a small quantity (().()l to 2%. referred to the weight of the substance to be protected) of the compounds of the formula l suffices to achieve good protection from oxidation. The antioxidant may be incorporated with the material to be protected. for example. direct. that is to say by itself. or in combination with other additives such as plasticizers. pigments. light filters. optical brightners. and/or with the aid of solvents. The antioxidative effect of the compounds of the formula I l) is evident also in the exposure test since these compounds can prevent or strongly reduce any oxidative process caused by exposure to light. for example the yellowing of polyvinylchloride.

The symbols used in the formulae of the present description. such as R,. R m. n. have throughout the Manufacturing Instructions for Starting Products (A) The starting material of the formula (6) C(CH 93 HO" -CH NH CH 011 I C(CH5)3 may be prepared in the following manner:

While cooling it to at most 20C. a solution of 82.4 g of l-hydroxy-2.o-di-tertiary butylbenzene in 470 ml of glacial acetic acid is mixed first with l35 ml of pyrophosphoric acid and then continuously within one hour with 40.4 g of acrylylrnethylolamide. The batch is stirred until all has dissolved and kept for 2 days at room temperature in a stoppered flask. during which g ofa by-product [2,2,6.6'-tetra-tertiary butyl-4.4'- methylenebisphenol] precipitate. This precipitate is suctioned off and the filtrate stirred into 2 liters of water. The tough precipitate formed is thoroughly stirred with fresh water, whereupon it crystallizes right through. The material is triturated and washed with water until it is free from acid. Yield: about l09 g ofthe compound of the formula 6 corresponding to 94% of theory. Melting point: 1 12 to l l3C. after recrystallization from cyclohexane.

In an analogous manner the starting materials of the following formulae are obtained:

CH -NH- -CH=CH W melting at l55 156C (B) The compound of the formula a a O H HO- bH NH-CCH C].

may be prepared in the following manner:

a. While cooling a solution of 82.4 g of 2.6-di-tertiary butylphenol in 480 ml of glacial acetic acid at C. I20 ml of pyrophosphoric acid and then continuously within l hour 54.4 g of chloroacetylmethylolamide are addedv The batch is stirred overnight and then kept for l day in a stoppered flask. whereupon part of the reaction product crystallizes out; it is stirred into 2 liters of water. and the precipitate is washed free from acid. whereupon it yields about 1 15 g 92% of theory) of the compound of the formula l4) melting at 152 153C after recrystallization from cyclohexane.

In identical manner the compounds of the following formulae are obtained:

(47) rcnp 0 ll HO GH NH C CH Cl CH5 melting at 143 144C Ho- "CHZ NH C BIO-Q CH NH c CH c1 melting at 157 [59C CH tough resin k CH NH C CH C1.

" 5 melting at 57 (CH3)5C H CH NH C CH Cl [now-crystalline mix-- ture of positional i'somers] 11 Another method for the manufacture of the compound of the formula 14) is the following:

b. A solution of 257.5 g of 2.6-di-tertiary butylphenol in 375 ml of 100% acetic acid is mixed with 170 g of chloroacetylrnethylolamide and while stirring it. hydro- 5 80% of the theoretical ofthe compound of the formula 5 EXAMPLE 1 A solution of 12 g of the compound of the formula (6) and 3.46 g of n-propylmercaptan in 70 ml of abso- 3U lute ethanol is mixed with a freshly prepared solution of 01 g of sodium in 5 ml of absolute ethanol. whereupon the mixture heats up slightly by itself. It is kept for 2 hour under nitrogen and then heated for /2 hour at 60C. the solvent is expelled under vacuum. the oily By using octanthiol-l instead of n-propylmercaptan. the compound of the formula c (0H O 11 1 a m (51 a) HO ori NH 04: on -$4 51 c (CH3)5 melting at 48 to 49C. is obtained.

In an identical manner the corresponding compounds that contain the residue (CH CH;, or CH- r ,-OCOCH;, instead of the n-propyl residue. and also the compound of the formula u R -NHC CH -CH -S- melting at 158 160C.

In an identical manner ethanedithiol and the intermediates of the formula (45) or (46) respectively furnish the substances 0 H H 2 H-NH-C-CHCHS i melting at 159 161C melting at 1 149.5%.

residue is taken up in 200 ml of chloroform and extracted by successive agitation with 100 ml of N- sodium hydroxide solution and with 2 X 150 ml of water. The organic phase is dried over sodium sulphate and the solvent distilled off under vacuum. The residual thick oil crystallizes slowly through when kept for several months.

Rapid crystallization occurs when the oil is seeded and thoroughly stirred for some time with 200 ml of petroleum ether. After filtering and drying there are obtained about 10.5 g 69.5% of theory) of the compound of the formula (51) 0on o EXAMPLE 2 A solution of 14.5 g of the compound of the formula (6) in 100 ml of absolute ethanol saturated with H. ,S is mixed with a solution of 0.1 g of sodium in ml of absolute ethanol and H S gas is slowly passed through the solution for 6 hours. The solvent is then expelled under vacuum. The oily residue is taken up in 250 ml of benzene and agitated with ml of ZN-NaOl-l. the benzolic phase is washed neutral with water. treated with sodium sulphate and active carbon and the solvent is expelled under vacuum. to yield 13.5 g 88% of theory) of the compound of the formula H ---CH NH CH CH S (JI'lg-CHg-CII melting at 82C.

CH G. (7) c p CH NH C CH GH ,5 (CH c 5 2 melting at 155 157C after recrystallization from formula (55) in which k 5. After recrystallization carbon tetrachloride and then from benzene. II) from ethanol this product decomposes at about l00C. When a correspondingly smaller quantity of sulphur EXAMPLE 3 is dissolved in the methanolic sodium sulphide solution. A solution of 2.88 g of crystalline sodium sulphide of all other conditions being identical, the compound of 61? strength in 100 ml of methanol is mixed with 14 g the formula (55) with k 2 is obtained; it melts at 178 of the compound of the formula (14) which dissolves 180C.

rapidly and a slightly exothermic reaction sets in. After hour the batch is heated for V: hour at C. then EXAMPLE 5 cooled. the precipitated sodium chloride is suctioned A solution of 4.96 g of thiophenol in 45 ml of molar off and the solvent expelled under vacuum. The crystalabsolute ethanolic sodium ethylate solution is mixed line residue is thoroughly washed with water and yields under nitrogen with a solution of 14 g of the compound about 13.2 g 100% of theory) of the compound of of the formula 14) in 150 ml of absolute ethanol. A the formula slightly exothermic reaction sets in immediately and 11 ll HO CH -NH-CCH (S) CH -0-HN-CH -OH (0H (x03 in which it 1. After recrystallization from carbon sodium chloride settles out The batch is refluxed for tetrachloride it melts at l86* 187C. 15 minutes and the precipitated sodium chloride is By a similar reaction chloroacetic acid-(3-tertiary suctioned ff- Yi ld; 2.6 g of theory). The buty]-4-hydroxy-S-methylphenyl)-methylamide 0f Ih filtrate is freed from the solvent under vacuum. the formula 7) furni he the compo n of the formula crystalline residue dissolved in 200 ml of chloroform (56) (ca C( i 5 5 q l 5 5 N I CH -NH-C-CH S-CH 0HN-CH -OH melting 186 187C and thoroughly agitated with 100 ml of 2N-sodium EXAMPLE 4 hydroxide solution and with 2 X 100 ml of water. The A solution of 2.88 g of crystalline sodium sulphide of 50 extracts are dried with sodium sulphate and the chloro- 6l% strength in 100 ml of methanol is mixed with 2.88 form is expelled under vacuum. to yield a crystalline gof sulphur; the batch is refluxed for 10 minutes. then residue of about 17.3 g 100% of theory) of the cooled again to room temperature and mixed with 14 g compound of the formula CH (57) K O u ao-ca -NH-c-ca -sof the compound of the formula 14) which dissolves which after recrystallization from cyclohexane melts at while the solution is heating up. and a short time later 65 1 15 -1 16C. a precipitate begins to form. The whole is refluxed for When the corresponding mercaptans (or ethanedi- V2 hour. allowed to cool. suctioned and the filter resithiol) and chloroacetic acid amides (see Manufacturdue is thoroughly washed with water. to yield about ing Instructions 81 are used. under otherwise identical 10.8 g 67.4% of theory) of the compound f h conditions. the compound of the formula In a similar manner to that used for the manufacture The residue is subjected to fractional recrystallizaof the compounds in Table I the compounds of the tion from V2 litre of carbon tetrachloride to yield varifollowing formulae are obtained: ous fractions of the compounds of the formula (72) (CH C I melting at 162 164C II (CH H -NH-CCH -S-C H O--{JH boiling at 190 197%) under 0.0M mm Hg (mixture of positional isomers),

ll HO CH NH-C-CH (S-CH -S-CH -C-NH-CH -OH (on C(GH 60 EXAMPLE 6 in which I has different mean values (from 2 to 5) which further contain 1 to 2 mols of carbon tetrachloride of crystallization which is given off quantitatively While stirring a solution of 15.6gofthe compound of only after heating for 2 to 3 hours at l to 140C the formula 14) in I ml of absolute ethanol under under a high vacuum of 0.00l mm Hg.

nitrogen. 5.47 g of polythioformal H(SCH- .-)7SH [I From the first crystalline fraction there is thus ob- =4 on an average]and immediately afterwards 50 m] of tained a product of the formula 15) in which I has an N-absolute ethanolic sodium ethylate solution are average value of 5 and which melts within the range stirred in. When the exothermic reaction has subsided. from to the batch is stirred on for 2 hours and the precipitated Most of the following crystalline fractions are less sodium chloride [2785 g 97.6% of theory) is sucuniform and their mean !-values are lower.

M LE 7 which decomposes at 101 205C. This salt is soluble A Solution of 2'81 g of penmervthritoptetmthiw in water. ethanol. benzene and warm carbon tetrachlt glycollate in 40 ml of dimethylformamide is mixed with 8.1 g of the compound of the formula l4) and within 5 EXAMPLE 9 2 hours 2.6 ml of lON-sodium hydroxide solution are A solution of 19.25 g of the ester of the formula (bl stirred in dropwise under nitrogen. The batch is stirred in St) ml of normal. absolute ethanolie sodium hydrov in a stoppered flask for another 20 hours and then ide solution are hydrolyzed as described in Example H. vigorously stirred into 800 ml of water. The precipitate The resulting Solution of the sodium salt of the formula is suctioned off and thoroughly washed with water. to l( (74) is cooled to room temperature and mixed with a yield 8.1 g 8 l7c of theory) of the compound of the solution of 4.44 g of chromic chloride (CrCl o H O) in formula 45 ml of absolute ethanol. whereupon sodium chloride 16) (cH c O HO II II I CH NHC-CH SCH -C-OCH C- I C The product is best purified by chromatography on immediately begins to settle out. The batch is boiled silica gel with an ascending series of eluants (benzene under a slight reflux for /2 hour and the precipitated chloroform). This furnishes the substance as a chlorosodium chloride (2.87 g 98.4% of theory) is sucform adduct from which chloroform can be quantita- 1 tioned off. The filtrate is completely evaporated under y ehmmilted y y i g for 1 h at 330C vacuum. The blue-grey powdery residue is completely undsr 0-001 mm meltmg range from 101 m freed from impurities by being dissolved in 300 ml of l09 C. xylene and agitated with 2 X 201) ml of water. Then 200 EXAMPLE 8 ml of xylene are distilled off under atmospheric pres- A solution of 19.25 g of the ester of the formula sure and the remainder under vacuum. The green. solid II EO-Q-CH C CH S CH 0C O CH 1 C CH in ml of normal absolute ethanolic or methanolic residue is dried for 3 hours at 50C under a high vacsodium hydroxide solution is boiled under a slight reuum and yields about 18.6 g 97% of theory) of the flux under nitrogen for 2 hours or kept for 20 hours at chromium salt of the formula c c 5 HO---@---CH NH c CH s H o-o Cr room temperature. After this time the hydrolysis is which turns at about l()5C into a glassy. soft product. substantially completed as can be shown by back-titrating against phenolphthalein. The solvent is then com- 55 EXAMPLE l0 pletely distilled off under a water-jet vacuum at 35C.

to furnish a glass-hard. friable residue (after drying in a A solution of 7 g of the sodium salt of the formula desiccator) weighing about l9.5 g l0O'7c of theory). (74) in ml of water is mixed with a solution of 2 g being the compound of the formula of nickel chloride (NiCl b H2O) in 50 ml of water.

II a. GHQ-CH NH O CH S CH OC 0 Na '7) ctcu HO CH2 NH C(CH5)5 which decomposes at l04C after reprecipitation from a mixture of ethanol and diethyl ether and is soluble in water.

EXAMPLE 12 a. A solution of [6.9 g of the thiuronium salt of the formula (87) in 100 ml of water free from oxygen is stirred at C into 120 ml of oxygen-free N-sodium hydroxide solution. The insoluble phase is suctioned off 6 C CH (7* t O HO H -NB-CCH S-CH COO N].

C 5 2 The salt is soluble in benzene and turns into a soft. and the filtrate rendered slightly acidic with 100% glassy substance at about [C. it probably still con- 15 acetic acid. the precipitate is suctioned off and thortains water of crystallization. After having been dried oughly washed with oxygen-free water. to yield about 6 for 3 hours over phosphorus pentoxide at [20C under g 4 f the ry) of the merc pto ompound of he 0.0M mm Hg it dissolves only incompletely in benzene. formula C CH C In an identical manner as the salts of the formulae 1 75) and (76] it is possible to manufacture the salts of the formula (7?) qtca 0 C(CH5)2 from suitable inorganic salts and the sodium salt of the formula 74).

which melts at 146* l47C after recrystallization from 70% aqueous methanol.

b. A solution of 390 g of Na S (containing 40% of water of crystallization) in 3.6 litres of methanol is filtered to remove a small insoluble residue. H 5 gas is introduced to saturation and then a solution of 187 g of the compound 14) in L4 litres of methanol is added. The batch is stirred on for 4 hours while passing a weak current of hydrogen sulphide.

The solvent is then completely expelled under vacuum and the crystalline residue is taken up in 2.5 litres of oxygen-free water. If necessary. an insoluble residue is filtered off. While stirring well. ml of l007c acetic acid are added. whereupon the product settles out first in smeary form but afterwards it crystallizes right through quite rapidly.

For purification the reaction product is dissolved in 2 litres of oxygen-free N-sodium hydroxide solution: the insoluble phase is suctioned off and the filtrate is neutralized with acetic acid. The precipitate is filtered off and thoroughly washed with water. to yield 132 g 71% of theory) of the compound of the formula(l8).

EXAMPLE 13 A mixture of 7.8 g of the compound 18). 0.75 g of parat'ormaldehyde and 0.l g of p-toluenesulphonic acid in 50 ml of benzene is refluxed for 30 minutes. then ith ml of N-sodiumhydroxide solution and then cooled. thoroughly agitated with 50 ml of N-sodium thoroughly with water and dried-over sodium sulphate. hydroxide solution and then several times with water After having removed the solvent under vacuum a and the benzolic phase is treated with sodium Sulphate r i f 10- g r f h ory) of h mpoun f and active carbon. Removal of benzene under vacuum 5 the formula furnishes the product of the formula 9) (Kon I! O H II Q-QCH NH CH s 2 OH ll H0- CH NH-C-CH S- 2 2 ,cn-Q 0(011 as an oily residue which crystallizes right through after a few days. It melts at 104 to l06C after recrystallization from benzene.

I u I IS obtained. During the recrystallization from carbon I h 3: f i' g g l' group 35 tetrachloride the solvent is incorporated and given off pp e Tare spectrum quantitatively only after heating for minutes at EXAMPLE under 0001 mm Hg. Melting point: 108

A mixture of 10 g of the compound (18). L8 g of In analo I I gous manner com ound 18) with n-he benlslldehfrde f g of p'lolueneslflphomc m taldehyde. lauraldehyde. stearzjldehyde. with furfur l l5n of benzfine boned for 7 hours PPQ and with cyclohexanone respectively furnishes the equipped with a water separator. then cooled. agitated Compounds f h f l C(CH ao-ca mn-c-ca s- 2 2 ,C'rH -fcli H C(CH 2 melting at 82 to 84C C 3 5 0 (22a) H H NH--CH S C 2 2 QKT CH a 2 melting at 84 to 89 6'.

c (CH O n (22b) no ca -rm-c-cn -scH(cH -l;r1

meltin at to 95C.

( 5) gtcrr C(CH melting at 95 to 105C o n HO Q CH -Mi-C-CH -S- EXAMPLE a bath temperature of C under a water-jet vacuum I and drying is performed for 6 hours under identical conditions. The residue is the sodium salt of the compound of the formula 18) in form of a friable. hard substance.

The product is dissolved under nitrogen in 40 ml of dimethylformamide and 3.4 g of bromoform are added.

155 Grams of the compound (18) are dissolved under nitrogen in ml of N-absolute methanolic sodium ethylate solution. and 3.12 g of trans-1.4- dichloro-butene-( 2) are added. When the strongly exo thermic reaction has subsided. the batch is stirred for another 12 hours in a stoppered flask and the precipi- Z5 tated sodium chloride (2.4 g 827r of theory) is suc- The whole kept Overmgm m a stoppered flfisk and tioned off. The filtrate is completely evaporated and boned for 3 hqurs E Shght reflux under l the residue treated with 50 ml of N-sodium hydroxide h f and surrFd 400 l l the solution. washed free from alkali. and then dried. to of a h'gh'speed surrer- The P Sucuoned 56 g (z 93% of them-v, of the campound of the 30 off and thoroughly washed with water. to yield 12.5 g

f m 100% of theory) of the compound of the formula C(GH II I Y H0@CihdlHG-CH SCH -CH=CH-CH -S-CH -C-NH-GH -Q0:I

I (K011 (5 (t an C(CH5)3 II H c11 -NH-cctt -s GH which after recrystallization from carbon tetrachloride 50 During recrystallization from carbon tetrachloride the contains 2 mols of carbon tetrachloride of crystallizasolvent is incorporated and given off quantitatively tion. It melts at 101 103C. it loses its carbon tetraonl after heating for 1 hour at C under 0.001 mm chloride only after having been heated for l hour at H Th subst nc soft ns in glassy form at 113 150C under 0.001 mm Hg. The compound free from 115C. carbon tetrachloride melts at 91 101C. 55 The above product is also accessible by the use of In an analogous manner compound 18) with 2.3- chloroform instead of bromoform and also in an alcodichloropropene-( l l. with methylenechloride or -broh li ol i Wllh 1.4-dibromobutane and With 118- In an analogous manner ompound penta dibmmoocmne respectively furnishes the Compounds erythritol-tetrabromide and with hexachloroethane of the formula m respectively furnishes the compounds of the formula 30. melting at 88 to 89C 36. melting at 134C and 31 melting at t 1C 37. melting at 216 217C.

32. melting at 143 to 147C 33. melting at 70 to 78C. EXAMPLE n A mixture of 15.6 g of the compound of the formula EXAMPLE 65 (14) and 12.4 g of powdered sodium thiosulphatej 124 Grams of the compoound 18) are dissolved H O in 200 ml of 80% aqueous methanol is stirred and under i r g n in 40 ml of N-abmlute ethunolic refluxed for 1 hour. during which everything dissolves ethylate solution. The solvent is completely espelled at idl The lvent i then completely expelled under (as) t Z(CH 110G.- H NH melting at 172 178C, which is soluble in benzene.

EXAMPLE 18 A solution of 15.6 g of the compound of the formula (14) in 200 ml of ethanol is mixed with 8.1 g of powdered sodium thiocyanate and the whole is heated to the boil with stirring. during which all dissolves. After a a short time NaCl begins to settle out. The batch is refluxed for 3 hours. the precipitated NaCl is suctioned off and the filtrate is evaporated under vacuum. The crystalline residue is washed with water and recrystallized from a small quantity of methanol; the product melts at 143.5 to 145C. A typical thiocyanate band appears in the infrared spectrum at 4.6m.

II HO-""CH NH C CH SCN EXAMPLE I) Test Method A The panel obtained as described is cut up into narrow strips which are allowed to age in an oven at 140C until the naked eye can detect distinct fissures.

TABLE Ill Compound of Hours until Compound of Hours until formula fissures form ula fissures added appear added appear (52] 200 (05) 150 (|k=5 200 179) 110 (Sol 151) (NH 551) (Pill lOil (e29 1H4] I511 lh-H 250 nil 5 Test Method B The panel is shredded. 5 Grams of these chips are heated at C in a reactor tube connected with an absolute pressure gauge. in an atmosphere of pure oxygen under a pressure of 700 mg Hg. By measuring the drop in pressure the induction time taken to reach the steep rise in the oxygen consumption can be deter- 50 vNa mined. The resulting oxidation products are absorbed with the aid of a Linde molecular sieve 5A and of potassium hydroxide so that in each case the pressure measured corresponds to the residue of pure oxygen. Since many compounds develop their full antioxidative effect only at a lower temperature. the test is also performed at 100C.

TABLE IV Added to compound of Induction time in minutes the formula at 160C at 100C (51] l5 I4 500 (521 541) on non (57I 2H 7 Illll (S91 12 5(1 lxxl (fill) 5U 3U lltlll (611 3. J 0011 nil 1 5t) EXAMPLE 20 The antioxidative effect of the compounds of the formula (1) can also be demonstrated in the test in which PVC panels are exposed to light. After PVC panels finished in this manner have been exposed to the fadeometer or the xeno test a distinct inhibition of yellowing is observed.

For these tests a mixture of suspension-PVC and commercial thermostabilizers and lubricants is formulated from 100 parts of suspension-PVC 2 parts of a tin stabilizer containing sulphur 2 parts of a lubricant based on esters of higher fatty acids 0.5 parts of a compound of the formula l This mixture is turned into a sheet on a calender at C which is then treated on a press at C under a pressure of 40 kg/cm to form a panel 1 mm thick. Panel sections manufactured in this manner are then exposed for 2000 hours in a xeno tester 150 or for 500 hours in a fadeometer (carbon arc).

Whereas the panels that do not contain an inhibitor of the formula (1) turn distinctly brownish after 800 hours in the xeno test or after 300 hours in the fadeometer. panels incorporating a compound of the formula (51) edfiiprising an l*l C(Cl-l residue instead of the propyl residue 55. 60. 78. 81 or 85 Show not the least sign of a change after the times indldted.

27 28 We claim: I I 6. Carboxylic acid amide according to claim 1 of the l. Carboxylic acid amide of the formula formum C I H3 H C- C CH 9 l 3 '5 O u CH NH-C- (CH -S [Q] 7 H H -NHCCH S ;CH

H C- IS 3 ?CH in which X is methyl or tertiary butyl. m is the integer 3 l or 2. O is alkylidene having 1 to 20 carbon atoms. 30 cycloalkylidene having 5 or 6 carbon atoms methylene substituted by phenyl or furyL alkylene having I to [0 Carbon atoms alkenylene huvmg Carbon moms 7. Carboxvlic acid amide according to claim 1 of the or a 3. 4. 5 or 6 valent saturated aliphatic hydrocarbon formula radical having 1 to 6 carbon atoms and p is an integer 35 which is equal to the valency of the radical.

2. Carboxylic acid amide of claim I in which X is methyl or tertiary butyl. m is the integer l or 2. Q is alkylidene having 1 to carbon atoms cyclohexyli- CH dene, methylene substituted by phenyl or furyl. alkyl- I 3 ene having 1 to 10 carbon atoms. alkenylene having l H c C 3 to 6 carbon atoms. or a 3. 4. 5 or 6 valent saturated 5 O aliphatic hydrocarbon radical having l to 6 carbon H atoms and p is an integer which is equal to the valency HO H2 NH"c CH2 S of the radical or 3. Carboxylic acid amide according to claim I, H c. g wherein X represents tertiary butyl and is located in 5 ortho-position to the hydroxyl and the amido-methyc H lene residue is located in para-position to the hydroxyl. 3

4. Carboxylic acid amide according to claim 1 of the 2 formula 8. Carboxylic acid amide according to claim 1 of the H C- G -CH formula H H NHC-CH S- 2 2 /CH (CH Q H s 5. Carboxyllc acld amlde according to claim 1 of the 5 ll 2 formula H H --N'HCCH -S- 2 2 C CH2 \CH -CH/ FHB H C- (I: CH3 2 2 6U H C'- CH ll HO H -NH-c-cH -s- 2 CH-(CH H 2 6 H C- C -C 0 9. Carboxylic acid amide according to claim 1 of the 2 formula UNITED STATES PATENT OFFICE AGE 1 of 2 CERTIFICATE OF CORRECTION Patent No. 3,927,091 Dated December 16, 1975 Inventor(s) He'lmub Huber-Emden, at 8.1

It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

Cover page [73] Assignee, should read CIBA-GEIGY AG, Basle, Switzerland Column 7, first formula,

2 9 CH (|3CH should read -CH -(|3-CH CH CH Column 15, Table I, No. 64, that portion of the formula cH cH scH c-m\I-cH should read Q CH SCHQ C HN CH2 o PAGE 2 of 2 UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. q q27,0g1 Dated December 16, 1975 Inventor(s) Helmut Huber-Emden, at 8.1

It is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown below:

Column 15, Table I, No. 65, that portion of the formula GH -CH S-CHg-C-HN-CH should read -CH '-CH 'SCH -I-Il I-CH Signed and Scaled this Twenty-ninth Day Of November I977 [SEAL] A nest:

RUTH C. MASON LUTRELLE F. PARKER Arresting Officer Acting Commissioner of Patents and Trademarks 

1. CARBOXYLIC ACID AMIDE OF THE FORMULA
 2. Carboxylic acid amide of claim 1 in which X is methyl or tertiary butyl, m is the integer 1 or 2, Q is alkylidene having 1 to 20 carbon atoms, cyclohexylidene, methylene substituted by phenyl or furyl, alkylene having 1 to 10 carbon atoms, alkenylene having 1 to 6 carbon atoms, or a 3, 4, 5 or 6 valent saturated aliphatic hydrocarbon radical having 1 to 6 carbon atoms and p is an integer which is equal to the valency of the radical Q.
 3. Carboxylic acid amide according to claim 1, wherein X represents tertiary butyl and is located in ortho-position to the hydroxyl and the amido-methylene residue is located in para-position to the hydroxyl.
 4. Carboxylic acid amide according to claim 1 of the formula
 5. Carboxylic acid amide according to claim 1 of the formula
 6. Carboxylic acid amide according to claim 1 of the formula
 7. Carboxylic acid amide according to claim 1 of the formula
 8. Carboxylic acid amide according to claim 1 of the formula
 9. Carboxylic acid amide according to claim 1 of the formula
 10. Carboxylic acid amide according to claim 1 of the formula 